Supply, delivery, installation and commissioning of a Liquid Chromatography Single Quadrupole Mass Spectrometry System

Descriptions

This proposal aims to acquire a liquid chromatography single quadrupole mass spectrometry system to be used solely for ion pairing experiments. This system will be dedicated to the separation and analysis of natural and synthetic biomacromolecules, including short RNA/DNA based oligonucleotides, proteins, peptides, and peptoids as examples. It will integrate complex separation of these biomolecules and their impurities, with direct quantification via UV-absorbance, mass measurement via quadrupole mass section and quantification of impurity profile. Since many of these biomolecules rely on compound purity for their biological activity, direct quantification of the target compound and impurity profile will be critical for evaluating their intended quality and performance, analytical method development for quality control and generate data that can be used to optimize synthetic routes and methods for these biomolecules.