Closed
Toxicology and Safety Pharmacology Studies
Descriptions
DSTL have a requirement for a contractor to carry out toxicity and safety pharmacology testing of an ovine polyclonal antitoxin in both rodents and rhesus macaques to identify the maximum tolerated dose administered by intravenous infusion that does not cause life-threatening pathology. The data obtained from this work will be used to support a clinical trial application and select the first in human dose. The testing should be undertaken in compliance with ICH guidelines.
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